GENESIS system - Massively Scaled Single-Cell Sequencing GENESIS system - Massively Scaled Single-Cell Sequencing – Witec AG

Art No | 20103
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Massively scaled single-cell sequencing. Hundreds to millions of cells per sample.

Description

The Genesis System enables scientists to analyze and interpret cellular behavior and to collect previously inaccessible cell-based information for improved results in applications such as

single-cell cytometry, single-cell proteogenomics, single-cell transcriptomics, rare-cell enumeration, and immune monitoring.

Whether studying hundreds or millions of cells the Genesis System provides a practical, scalable, and efficient approach to accurately analyze previously undetectable or rare cells.

Meet the Genesis System

The Genesis System enables a range of single-cell applications with Celsingle™ or Celselect™ Slides supporting hundreds to millions of cells per experiment. Throughput is flexible across one or two slides per run, which includes an automated workflow. The Genesis System is also an open and customizable system that supports method development and protocol optimization to develop your own applications.

 

CelsingleTM Technology

Celsingle™ Slides capture and isolate single cells with a gentle, gravity-based approach.  Discrete microwells allow a single cell to be paired with a unique cellular barcode and unique molecular indices for desired applications, such as gene expression or protein quantitation. The Celsingle process is open to support users that want to optimize, modify, or create new single-cell applications.  The scalability of this approach is unmatched and has the potential to provide a 10x increase in cell throughput compared with other technologies. The Celsingle Slide design enables unique possibilities, including visualization and QC of cells prior to lysis, as well as treatment or challenge of cells.

Key applications CelsingleTM slides:

Single-Cell Cytometry
Limitless protein detection on millions of cells

Single-Cell Proteogenomics
Combined RNA and limitless protein detection

Single-Cell Transcriptomics
Scalable and efficient RNA detection

 

CelselectTM Technology

Celselect™ Slides capture and isolate individual immune cells, rare cells or CTCs based on their size utilizing microfluidics and 56,400 individual microchambers. Isolated cells can be stained for immunofluorescent applications such as enumeration, FISH, or enriched for downstream methods such as cell-culture or single-cell genomics. The high capture efficiency and customizability paired with excellent sensitivity and specificity make the Celselect™ Slides the ideal approach to follow tumor progression and response to therapy. The Celselect Technology is open to support users that want to optimize, modify, or create new protocols or custom reagent formulations.

Key applications CelselectTM slides:

Rare-Cell Enumeration

Rare-Cell Enrichment

 

Key Benefits

  • Unmatched sample and cell throughput flexibility - supports experiments from hundreds to millions of cells
  • Semi-automated workflow - on-instrument lysis and reverse transcription
  • Deep and accurate view of cell populations with >70% capture of input cells
  • Open system enables development and optimization of custom single-cell protocols
  • Open format enables optional visual QC, confirmation of cell capture rates, and cell characterization by microscopy
  • Scale from hundreds to millions of single cells with the Genesis System and different Celsingle formats
  • Limitless protein detection with no spectral overlap - push past the boundaries of traditional cytometry methods
  • No lasers, droplets, heavy metals, or harsh processes
  • No gating calibration
  • A very economical invest – save time and money
Genesis - Single-Cell Cytometry


Single-Cell Cytometry

High-parameter protein analysis that scales from hundreds to millions of single cells with the Genesis System

  • Limitless protein detection with no spectral overlap – push past the boundaries of traditional cytometry methods
  • No lasers, droplets, heavy metals, or harsh processes
  • No gating calibration
Genesis - Single-Cell Proteogenomics


Single-Cell Proteogenomics

The Genesis System enables characterization of both RNA and protein at single-cell resolution

  • Delivers best-in-class cell population resolution
  • Limitless protein detection with combined RNA measurement
  • Reduced risk of batch effects with higher cell throughput
  • No lasers, droplets, heavy metals, or harsh processes
Genesis - Single-Cell Transcriptomics


Single-Cell Transcriptomics

Achieve deep cell population resolution with the Genesis System and scale to millions of single cells

  • Interrogate large numbers of cells at once with high capture efficiency
  • Gentle gravity-based cell isolation without harsh droplet approaches
  • Achieve cost-effective tissue atlases with high cell numbers
Genesis - Rare-Cell Enumeration

Rare-Cell Enumeration

The Genesis System captures more rare cells, enables accurate enumeration and downstream analysis.

  • Highly-efficient capture of immune cells from common solution-based samples
  • Remove of greater than 99% of RBCs and WBCs
  • On-slide immunostaining, FISH analysis
Rare-Cell Enrichment

Rare-Cell Enrichment

The Genesis System captures and retrieves viable rare cells for any application with high efficiency.

  • Capture and retrieval of rare cells from blood, urine or tissue in less than 6 minutes
  • Highly-efficient capture of rare cells (1 in 1,000,000 cells)
  • Viable cells captured can be used for imaging, culture or downstream genomic analysis

What you can Do with the Genesis System

Characterize the tumor microenvironment: Investigate tumor heterogeneity and immune response before, during, and after treatment

Generate tissue atlases: Pan-tissue mapping of the human body to understand transcriptional profiles of particular cell types

Monitor the immune system: Detection of T and B cell phenotypes to understand disease response and its relation to treatment and ultimately to outcomes, with long-term potential for non-invasive detection of many immune-related issues

Analyze pathways: A powerful approach for unraveling the function of various signaling pathways across application areas (e.g. development or cell-cell signaling) and biomarker discovery in oncology

Trace cell lineage: Characterize the developmental mechanisms by which a single cell gives rise to tissues or multicellular organisms, or track the onset of cancer from its cell of origin

Genesis - Detect 100s of proteins on 100,000s of single cells.
Genesis - Celsingle Technology


Celsingle Technology

Celsingle™ Slides capture and isolate single cells with a gentle, gravity-based approach. Discrete microwells allow a single cell to be paired with a unique cellular barcode and unique molecular indices for desired applications, such as gene expression or protein quantitation. The Celsingle process is open to support users that want to optimize, modify, or create new single cell applications. The scalability of this approach is unmatched and has the potential to provide a 10x increase in cell throughput compared with other technologies. The Celsingle Slide design enables unique possibilities, including visualization and QC of cells prior to lysis, as well as treatment or challenge of cells.

Supplier

Celsee
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